Hi everyone, This is my first time posting and I'm not sure what to
expect. I guess I should tell you a bit about me before I pose some
questions that I would really appreciate feedback on. I'm 48 (male) and
battle treatment-resistant depression, gen...
View more
Hi everyone, This is my first time posting and I'm not sure what to
expect. I guess I should tell you a bit about me before I pose some
questions that I would really appreciate feedback on. I'm 48 (male) and
battle treatment-resistant depression, generalised anxiety disorder and
an alcohol use problem; all since I was in my early teens. It's been a
very tough road navigating treatments (anti-depressants, anxiolytics,
stimulants, anti-psychotics, mood stabilisers, ECT, TMS, CBT,
interpersonal therapy, medications to address my alcohol use, etc.) and
the devastating effects my condition has had on relationships. My
anxiety is well-controlled with a non-benzodiazepine medication at the
moment, but I expect to develop tolerance to it as has been my
experience in the past. I eventually found a SNRI anti-depressant 11
years ago that prevents me from living in a crippling abyss of
depression, but I'm left with persistent anhedonia that I now recognise
has been the long-standing reason for my inability to define a direction
for my life. With some unfortunate exceptions, I'm grateful for my
privileged access to excellent medical professionals in Australia and in
the US. I'm looking forward to consulting a psychiatrist who specialises
in the treatment of mood disorders, anhedonia in particular, and would
really like to hear about others' experience with anhedonia. Anhedonia
is the (relative) inability to experience pleasure. Although not always
present, is it the worst possible symptom of treatment-resistant
depression? I think that it is. How can anhedonia be successfully
treated? I was prescribed a selective dopamine receptor agonist, a good
idea and supported for the treatment of anhedonia by a small number of
clinical studies, but the risk of unpredictable "sleep-attacks" makes
driving too dangerous and so I won't take it. How do you cope with
anhedonia? In the long-term, it's paralysing for me and makes me
periodically suicidal. Life without pleasure is very difficult to
sustain. Is there any hope?